Abemaciclib Combo Therapy Improves Outcome in Certain Advanced Breast Cancer Patients

Abemaciclib Combo Therapy Improves Outcome in Certain Advanced Breast Cancer Patients
Adding abemaciclib to endocrine therapy can reduce the risk of breast cancer progressing in newly diagnosed postmenopausal women, according to interim results of a Phase 3 clinical trial. Italian researcher Angelo Di Leo presented the findings at the European Society for Medical Oncology Congress in Madrid, Sept. 8-12. The MONARCH 3 study (NCT02246621) involves hormone receptor (HR)-positive, HER2-negative advanced breast cancer. Dr. Angelo Di Leo, a cancer specialist at the Istituto Toscano Tumori's Hospital of Prato in Italy, made the presentation, which was titled "Abemaciclib as initial therapy for patients with HR+/HER2- advanced breast cancer." He was the study's lead author. MONARCH 3 is investigating the effectiveness of a combination of abemaciclib and endocrine therapy as an initial treatment for this patient population. Abemaciclib is a cyclin-dependent kinase (CDK) 4/6 inhibitor. CDKs are molecules that regulate cell proliferation and growth, and CDK4/6 is often overactive in breast cancers, allowing cancer cells to multiply uncontrollably. The ongoing trial involves 493 patients from 22 countries. It is randomizing participants to receive one of two combination therapies. One combo is abemaciclib and either Novartis' Femara (letrozole) or AstraZeneca's Arimidex (anastrozole). The other combination, which constitutes the control arm of the trial, is a placebo and either Femara or Arimidex. Twice as many p
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