Poor Prognosis for Breast Cancers Diagnosed After Negative Screening Mammography

Poor Prognosis for Breast Cancers Diagnosed After Negative Screening Mammography
While occurring at low rates, breast cancer cases diagnosed after a negative mammography screening are linked to poorer prognosis compared to those diagnosed after a positive mammogram, an observational study suggests. These findings highlight the need to improve early detection for these women. The study, “Breast Cancer With a Poor Prognosis Diagnosed After Screening Mammography With Negative Results,” was published in the journal JAMA Oncology. Interval breast cancers are those diagnosed between screening mammographies. In these patients, the last screening mammography came out negative. These cases represent approximate 15 percent of all breast cancers. Interval breast cancers include cancers that were missed on examination, as well as rapidly growing cancers, which tend to have poorer prognosis. Thus, identifying women at risk of breast cancer with a poor prognosis despite regular screening mammography could improve screening approaches for such patients. For this study, researchers evaluated women who developed breast cancer after a negative screening in an attempt to determine risk factors for the development of such cancers. They examined data from 306,028 women, 40 years or older, who underwent mammography screening between 2011 and 2014. The data was obtained from the Population-Based Research Optimizing Screening Through Personalized Regimens (PROSPR) consortium, which includes data from four centers – the Dartmouth Hitchcock Medical Center
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