Phase 3 Trial of Sacituzumab Govitecan Recruiting Triple-negative Breast Cancer Patients

Phase 3 Trial of Sacituzumab Govitecan Recruiting Triple-negative Breast Cancer Patients
A Phase 3 trial is recruiting participants to examine the effects of sacituzumab govitecan in patients with metastatic triple-negative breast cancer (TNBC) who failed to respond, or relapsed after at least two prior treatments. Patients are being recruited for the trial (NCT02574455) across several clinical sites in the United States, Canada, France, Belgium, Spain, the United Kingdom, and Germany. Participating centers in the U.S. can be found here. Sacituzumab govitecan, made by Immunomedics, is a drug-conjugate compound that combines an antibody against the TROP-2 protein — found in many tumor types, including breast, colon, lung and prostate cancers — with a toxic payload. Once bound to its target, sacituzumab govitecan releases the toxic compound into cancer cells. The treatment has already shown promise in metastatic TNBC patients who failed prior therapies, leading to partial or complete responses in 30%
Subscribe or to access all post and page content.