CHMP Recommends Tecentriq-Abraxane Combination to Treat Some Triple-negative Breast Cancers in Europe

CHMP Recommends Tecentriq-Abraxane Combination to Treat Some Triple-negative Breast Cancers in Europe
The  Committee for Medicinal Products for Human Use (CHMP),  an arm of the  European Medicines Agency , has recommended the approval of Tecentriq (atezolizumab) in combination with the chemotherapy Abraxane (nab-paclitaxel) as a first-line treatment for some advanced triple-negative breast cancers (TNBC). Specifically, the recommendation is for adult patients with locally advanced or metastatic cancer that cannot be removed by surgery, who have not received prior chemotherapy for their metastatic disease, and whose tumors test positive for the PD-L1 factor. It is based on findings from the IMpassion130 Phase 3 trial (NCT02425891), where the combination reduced the risk of disease progression or death by 38% and extended survival by seven months in the PD-L1-positive population, compared with Abraxane only. “This CHMP recommendation marks a breakthrough in the treatment of triple-negative breast cancer, an aggressive type of breast cancer with high unmet medical need,” Sandra Horning, Roche’s chief medical officer and head of global product development, said in a
Subscribe or to access all post and page content.