Study to Focus on Genetic Causes of Breast Cancer in African-Americans

Study to Focus on Genetic Causes of Breast Cancer in African-Americans
Most U.S. studies into the genetics of breast cancer were conducted in women of European ancestry, so it remains to be determined why African-American women are more likely to be diagnosed at younger ages, have more aggressive types of the disease, and die of breast cancer at higher rates than their white counterparts. To address this gap, Washington University School of Medicine in St. Louis researchers are designing a large study in African-American women with breast cancer to understand if their genetic risk is due to the same induced genetic mutations affecting white women. “We’ve had a revolution in genetic testing over the past 10 years,” the study’s senior investigator, Laura Jean Bierut, MD, the Alumni Endowed Professor of Psychiatry, said in a news release. “We’ve been able to identify many gene variants that contribute to a variety of cancers, including breast cancer. But as you examine the data, you realize most of these studies have been done in populations of European ancestry and that we don’t understand very much about the genetic causes of cancer in other populations, particularly in African-American women.” African-Americans are nearly twice as likely as white women to be diagnosed with triple-negative breast cancer, a more aggressive and harder-to-treat subtype, according to the National Cancer Institute, and they're more likely to die of their cancer. “Better understanding of the genetics of the disease in Africa
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.