Newly Discovered Enzyme Controls Metastasis in Breast Cancer

Newly Discovered Enzyme Controls Metastasis in Breast Cancer
UBC13 – a new STOP sign for breast cancer metastasis Breast cancer is the most common type of cancer afflicting American women and their second-leading cause of death, according to the American Cancer Society. The invasive forms of breast cancer are characterized by its ability of growing into healthy tissue. Once cancer cells reach the bloodstream or lymphatic system, they can promote breast cancer metastasis, i.e., the spread of the primary tumor to other body parts. Cancer lethality is related to this spread from the primary tumor. In the current issue of PNAS, a team of researchers at the University of California, San Diego School of Medicine found a new pathway regulated by an enzyme, UBC13, that targets breast cancer metastasis. The findings are posted in an article entitled, "Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade." UBC13 was a
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